The LiquiFace is the ideal solution for research applications requiring high-performance carbon isotope analysis of dissolved organic compounds. LiquiFace offers significant benefits for versatility and ease of use in liquid chromatography isotope ratio mass spectrometry (LC-IRMS).
Compound-specific isotope analysis of aqueous samples by liquid chromatography is highly advantageous for compound classes that are thermolabile or require derivatization making GC-based separation less attractive. Polar compounds such as carbohydrates, amino acids, alcohols, organic acids, and peptides make ideal candidates for LC-IRMS, and the technique has been employed to great success in food and biogeochemistry applications.
LiquiFace is an interface for the LC system to provide quantitative online conversion of the carbon in the separated organic compounds to CO2, followed by extraction from the aqueous phase into the gaseous phase and subsequent δ13C analysis by the IRMS system. The instrument uses a “wet-chemical oxidation” which delivers excellent isotopic precision, accuracy, and linearity. This level of performance means that LiquiFace covers a range of sample types with a complete independence upon sample concentration, making your analysis even simpler.